2. Signaling Pathways
  3. GPCR/G Protein
    Neuronal Signaling
  4. Cannabinoid Receptor

Cannabinoid Receptor

Cannabinoid Receptor

Cannabinoid Receptor

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Cannabinoid receptors are currently classified into three groups: central (CB1), peripheral (CB2) and GPR55, all of which are G-protein-coupled. CB1 receptors are primarily located at central and peripheral nerve terminals. CB2 receptors are predominantly expressed in non-neuronal tissues, particularly immune cells, where they modulate cytokine release and cell migration. Recent reports have suggested that CB2 receptors may also be expressed in the CNS. GPR55 receptors are non-CB1/CB2 receptors that exhibit affinity for endogenous, plant and synthetic cannabinoids. Endogenous ligands for cannabinoid receptors have been discovered, including anandamide and 2-arachidonylglycerol.

Cannabinoid Receptor Isoform Specific Products:

Cannabinoid Receptor Isoform Comparison
Cat. No. Product Name Effect Purity Chemical Structure
  • HY-W109442
    5Br-INACA
    		Control
    5Br-INACA is a precursor in the synthesis of synthetic cannabinoids.
    5Br-INACA
  • HY-168791
    8(R)-Hydroxy-9(S)-Hexahydrocannabinol
    8(R)-Hydroxy-9(S)-Hexahydrocannabinol is a metabolite of hexahydrocannabinol (HHC).
    8(R)-Hydroxy-9(S)-Hexahydrocannabinol
  • HY-150335
    Dehydrocannabifuran
    Dehydrocannabifuran (6-Methyl-9-isopropenyl-3-pentyldibenzofuran-1-ol) is a phytocannabinoid derivative.
    Dehydrocannabifuran
  • HY-168794
    11-Hydroxy-9(R)-hexahydrocannabinol
    11-Hydroxy-9(R)-hexahydrocannabinol is a phytocannabinoid metabolite.
    11-Hydroxy-9(R)-hexahydrocannabinol
  • HY-170702
    10α-Hydroxy-Δ8-THC
    10α-Hydroxy-Δ8-THC (10α-Hydroxy-Δ8-tetrahydrocannabinol) is a phytocannabinoid.
    10α-Hydroxy-Δ8-THC
  • HY-168795
    11-Hydroxy-9(S)-hexahydrocannabinol
    11-Hydroxy-9(S)-hexahydrocannabinol is a phytocannabinoid metabolite.
    11-Hydroxy-9(S)-hexahydrocannabinol
  • HY-108067
    SAD448
    		Agonist
    SAD448 is a CB1 and CB2 receptor agonist. SAD448 can lower intraocular pressure (IOP).
    SAD448
  • HY-W775346
    Delta8-THC acetate
    		Modulator
    Delta8-THC acetate (Delta8-tetrahydrocannabinol) is a psychoactive phytocannabinoid, that binds to cannabinoid receptor 1 (CB1 receptor), and exhibits anti-nausea, appetite-stimulating, and anti-inflammatory activities. Delta8-THC acetate exhibits probably neuroprotective efficacy and can be used in anti-anxiety and antidepressant research.
    Delta8-THC acetate
  • HY-170720
    CH-FUBIATA
    CH-FUBIATA is structurally similar to known synthetic cannabinoids.
    CH-FUBIATA
  • HY-W783639S
    Bzo-poxizid-d9
    Bzo-poxizid-d9 (5C-MDA-19-d9, Petyl MDA-19-d9) is deuterium labeled Bzo-poxizid. Bzo-poxizid is a synthetic cannabinoid that is a psychoactive substance.
    Bzo-poxizid-d<sub>9</sub>
  • HY-158814
    2-(2-Chlorophenyl)-1-(1H-indol-3-yl)ethanone
    2-(2-Chlorophenyl)-1-(1H-indol-3-yl)ethanone is a precursor in the synthesis of synthetic cannabinoids.
    2-(2-Chlorophenyl)-1-(1H-indol-3-yl)ethanone
  • HY-170744
    (±)-Cannabichromebutolic acid
    (±)-Cannabichromebutolic acid is structurally similar to known phytocannabinoids.
    (±)-Cannabichromebutolic acid
  • HY-122799
    Cannabigerovarinic acid
    		Control
    Cannabigerovarinic acid is a cannabinoid acid, which is found in Thai Cannabis.
    Cannabigerovarinic acid
  • HY-168792
    (±)-9-Nor-9α-hydroxy Hexahydrocannabinol
    (±)-9-Nor-9α-hydroxy Hexahydrocannabinol is a cannabinoid-type compound that has strong cannabinoid-like activity in both dogs and mice.
    (±)-9-Nor-9α-hydroxy Hexahydrocannabinol
  • HY-170042A
    5'-Hydroxy-9(R)-hexahydrocannabinol
    5'-Hydroxy-9(R)-hexahydrocannabinol is a phytocannabinoid metabolite.
    5'-Hydroxy-9(R)-hexahydrocannabinol
  • HY-168355
    Δ8-THC methyl ether
    		Ligand
    Δ8-THC methyl ether (compound 3) shows a good docking score (-10.167 kcal/mol) for CB2 receptor. Δ8-THC methyl ether has antinociceptive activity in mice.
    Δ8-THC methyl ether
  • HY-158943
    2-Fluoro QMPSB
    2-Fluoro QMPSB (QMDFPSB) is structurally similar to known synthetic cannabinoids.
    2-Fluoro QMPSB
  • HY-176077
    CHO-4′Me-5′Br-FUBOXPYRA
    		Activator
    CHO-4’Me-5’Br-FUBOXPYRA (CH-FUBBMPDORA) is an oxopyridine carboxamide that shares a similar structure to known synthetic cannabinoids. CHO-4’Me-5’Br-FUBOXPYRA demonstrates limited activation potential at both cannabinoid receptors CB1 and CB2.
    CHO-4′Me-5′Br-FUBOXPYRA
  • HY-170045
    (±)-9α-Hydroxy hexahydrocannabinol
    (±)-9α-Hydroxy hexahydrocannabinol ((±)-9α-Hydroxy HHC) is structurally similar to known phytocannabinoids.
    (±)-9α-Hydroxy hexahydrocannabinol
  • HY-129787
    PF-03550096
    		Agonist
    PF-03550096 is an orally active synthetic cannabinoid (CB) that selectively targets peripheral CB2 receptors with a Ki value of 7.9 nM. PF-03550096 has analgesic activity.
    PF-03550096
Cat. No. Product Name / Synonyms Application Reactivity
Cannabinoid Receptor Isoform Comparison

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